ET-2 (HUMAN, PIG, DOG)
endothelin 2
CAS: 123562-20-9
Molecular Formula: C115H160N26O32S4
ET-2 (HUMAN, PIG, DOG) - Names and Identifiers
ET-2 (HUMAN, PIG, DOG) - Physico-chemical Properties
| Molecular Formula | C115H160N26O32S4 |
| Molar Mass | 2546.92 |
| Appearance | powder |
| Color | white |
| Storage Condition | −20°C |
| MDL | MFCD00133306 |
| In vitro study | At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC 50 =0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. |
| In vivo study | Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr. |
ET-2 (HUMAN, PIG, DOG) - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | 26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| Hazard Class | 6.1 |
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CAS: 123562-20-9
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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CAS: 123562-20-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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